Shri Vile Parle Kelavani Mandal's
INSTITUTE OF PHARMACY, DHULE
Approved by PCI, AICTE, DTE
Affiliated to DBATU, Lonere & MSBTE Mumbai
INSTITUTE OF PHARMACY, DHULE
Approved by PCI, AICTE, DTE
Affiliated to DBATU, Lonere & MSBTE Mumbai
Assistant Professor
Qualification: MS. Pharm. (NIPER Kolkata), Ph.D. BIT Mesra
Specialization: Pharmaceutical Chemistry
Email ID: mohd.siddique@svkm.ac.in
Phone: +91_8809792075/8825383787
Experience: 9 Years
Interest Areas: Computational & Medicinal Chemistry
Research:
Industry Projects: Ongoing: (01)
Conferences/Workshops/Seminars attended: (11)
Academic Activities:
Awards
Professional Membership:
Recent Publications:
1. Yogeeta O. Agrawal, Kiran D. Patil1, Kamini R. More, Mohd Usman Mohd Siddique, Saad Alkahtani, Nada H. Aljarba, Md Saquib Hasnain, "Amelioration of Bioavailability through Formulating and Optimizing Azilsartan Entrapped Nanostructured Lipid Carriers and its Pharmacokinetic Assessment” The Journal of Drug Delivery Science and Technology, 2022 (Accepted, in press) (IF: 5.06)
2. Hussain A, Afzal O, Altamimi AS, Ali A, Ali A, Martinez F, Siddique MU, Acree Jr WE, Ali N. Preferential solvation study of (Z)-N-benzyl-2-{5-(4-hydroxybenzylidene)-2, 4- dioxothiazolidin-3-yl) acetamide (3) in {NMP (1)+ Water (2)} co-solvent mixture and GastroPlus software based in vitro simulation. Journal of Molecular Liquids. 2022 Jan 10:118491. (IF: 6.63)
3. Hussain A, Altamimi MA, Afzal O, Altamimi AS, Ali A, Ali A, Martinez F, Mohd Siddique MU, Acree Jr WE, Jouyban A. Preferential Solvation Study of the Synthesized Aldose Reductase Inhibitor (SE415) in the {PEG 400 (1)+ Water (2)} Cosolvent Mixture and GastroPlus-Based Prediction. ACS Omega. 2022 Jan 2. (IF: 4.13)
4. Sherikar A, Siddique MU, More M, Goyal SN, Milivojevic M, Alkahtani S, Alarifi S, Hasnain MS, Nayak AK. Preparation and Evaluation of Silymarin-Loaded Solid Eutectic for Enhanced Anti-Inflammatory, Hepatoprotective Effect: In Vitro–In Vivo Prospect. Oxidative Medicine and Cellular Longevity. 2021 Nov 10;2021. (IF: 7.31)
5. Siddique MU, Thakur A, Shilkar D, Yasmin S, Halakova D, Kovacikova L, Prnova MS, Stefek M, Acevedo O, Dasararaju G, Devadasan V. Non-Carboxylic Acid Inhibitors Of Aldose Reductase Based On N-Substituted Thiazolidinedione Derivatives. European Journal of Medicinal Chemistry. 2021 Jun 12:113630. (IF: 7.08)
6. Alshehri S, Hussain A, Ahsan MN, Ali R, Siddique MU. Thermodynamic, Computational Solubility Parameters in Organic Solvents and In Silico GastroPlus Based Prediction of Ketoconazole. ACS omega. 2021 Feb 11;6(7):5033-45. (IF: 4.13)
7. Mary SJ, Siddique MU, Pradhan S, Jayaprakash V, James C. Quantum chemical insight into molecular structure, NBO analysis of the hydrogen-bonded interactions, spectroscopic (FT–IR, FT–Raman), drug likeness and molecular docking of the novel anti COVID-19 molecule 2-[(4, 6-diaminopyrimidin-2-yl) sulfanyl]-N-(4-fluorophenyl) acetamide-dimer. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 2021 Jan 5;244:118825. (IF: 4.83)
8. Yasmin S, Cerchia C, Badavath VN, Laghezza A, Dal Piaz F, Mondal SK, Atlı Ö, Baysal M, Vadivelan S, Shankar S, Siddique MU. A Series of Ferulic Acid Amides Reveals Unexpected Peroxiredoxin 1 Inhibitory Activity with in vivo Antidiabetic and Hypolipidemic Effects. ChemMedChem. 2020 Oct 8;15:1-6. (IF: 3.54)
9. Mohd Siddique MU, Ansari A, Sinha BN, Jayaprakash V. Comparative Computational Studies on Selective CytochromeP450 1B1 Inhibitors. International Journal Bioautomation. 2020 Jul 1;24(3). (IF: 1.2)
10. Bose P, Siddique MU, Acharya R, Jayaprakash V, Sinha BN, Lapenna A, Pattanayak SP. Quinazolinone derivative BNUA‐3 ameliorated [NDEA+ 2‐AAF] induced liver carcinogenesis in SD rats by modulating AhR‐CYP1B1‐Nrf2‐Keap1 pathway. Clinical and Experimental Pharmacology and Physiology. 2020 Jan;47(1):143-57. (IF: 2.96)
11. Vinay R Sonawane.; Mohd Usman Mohd Siddique*.; Surender S Jadav.; Venkatesan Jayaprakash.; Barij N Sinha; "Cink4T, a quinazolinone-based dual inhibitor of Cdk4 and tubulin polymerization, identified via ligand-based virtual screening, for efficient anticancer therapy”, European Journal of Medicinal Chemistry 2019, (165), 115-132 (IF: 7.08)
12. Vinay R Sonawane.; Mohd Usman Mohd Siddique*.; Ibidapo S Williams.; Linda Gatchie; Sandip B Bharate.; Venkatesan Jayaprakash.; Barij N Sinha; "CYP450 enzymes, expressed within live human suspension cells, are superior to widely-used microsomal enzymes in identifying potent CYP1A1/CYP1B1 inhibitors: Identification of quinazolinones as CYP1A1/CYP1B1 inhibitors that efficiently reverse B[a]P toxicity and cisplatin resistance” European Journal of Pharmaceutical Sciences. 2019, (131) 177-194 (IF: 5.11)
13. Mohd Usman MS.; Tabassum Khair Barbhuiya.; Sandhya Rani.; Shilpi Mondal.; Chandan Kyal.; Rashmi Kumari.; Combined protein and ligand based physicochemical aspects of molecular recognition for the discovery of CDK9 inhibitor” Gene reports. 2018 Dec, 13; 212- 219 (1.5)
14. Mohd Usman Mohd Siddique.; Tabassum Khair Barbhuiya.; Barij Nyan Sinha.; Venkatesan Jayaprakash., "Phytoestrogens and their synthetic analogues as substrate mimic inhibitors of CYP1B1” European Journal of Medicinal Chemistry. 2019 Feb, 163; 28-36 (IF: 7.08)
15. Pattanayak Shakti Prasad.; Bose Pritha.; Sunita Priyashree.; Mohd Usman M U.; Lapenna Antonio "Bergapten Inhibits Liver Carcinogenesis by Modulating LXR/PI3K/Akt and IDOL/LDLR Pathways" Biomedicine & Pharmacotherapy. 2018 Dec 1;108:297-308. (IF: 7.42)
16. Nath Chandrani,; Badavath Vishnu Nayak,; Thakur Abhishek,; Ucar Gulberk,; Acevedo, Orlando,; Mohd Siddique Mohd Usman,; Jayaprakash, Venkatesan "Novel Curcumin-Based Pyrazoline Analogues as Selective Inhibitors of Human Monoamine Oxidase A” MedChemComm, 2018, (9) 1164-1171 (IF: 5.12)
17. Md.Wasimul Haque , Pritha Bose, Mohd Usman Mohd Siddique , Priyashree Sunita, Antonio Lapenna , Shakti P. Pattanayak, "Taxifolin Binds With Lxr (Α & Amp; Β) To Remodel Dmba- Induced Mammary Carcinogenesis Through Mtor/Maf-1/Pten Pathway”, Biomedicine and Pharmacotherapy, 2018 Sep 30;105:27-36. (IF: 7.42)
18. Haque MW, Siddique MU, Bose P, Pattanayak SP. Taxifolin possesses anti-cancer activity on the 7, 12-Dimethylbenz (a) anthracene-Induced breast cancer in the sprague dawley rats by remodeling nuclear factor Erythroid 2-Kelch-Like ECH-Associated Protein 1-Heme Oxygenase 1 and anti-oxidant pathways. Pharmacognosy Magazine. 2018 Jun 1;14(55):110. (IF: 1.51)
19. Mohd Usman Mohd Siddique.; Barij Nyan Sinha.; Venkatesan Jayaprakash., Comparative Shape and electrostatic study of BNUB-10 with TMS as a selective CYP1B1 inhibitor: Assessment of Active site of CYP1B1 by binding mode analysis using SiteMap tool, Indian Journal of Pharmaceutical Education and Research 2018, 52(1) 159-165, doi:10.5530/ijper.52.1.18) (IF: 0.501)
20. Mohd Usman Mohd Siddique.; Surender Singh Jadav.; Geraldine Graser.; Philipp Saiko.; Thomas Szekeres.; Venkatesan Jayaprakash.; Barij N. Sinha., Design, Synthesis and biological evaluation of diazeno-thiazole derivatives as ribonucleotide reductase inhibitors. Journal of Pharmaceutical Chemistry 2017, May 25;4(2):20-4.
21. Bagchi S, Alia U, Mohammad F, Siddique MU. High throughput virtual screening-based discovery of dengue protease inhibitor. Journal Of Pharmaceutical Chemistry. 2017 Aug 9;4(3):35-40.
22. Mohd Usman Mohd Siddique.; McCann, G. J.; Sonawane, V. R.; Horley, N.; Gatchie, L.; Joshi, P.; Bharate, S. B.; Jayaprakash, V.; Sinha, B. N.; Chaudhuri, B., Quinazoline derivatives as selective CYP1B1 inhibitors. European Journal of Medicinal Chemistry 2017, 130, 320- 27. (IF: 7.08)
23. Mohd Usman Mohd Siddique.; McCann, G. J.; Sonawane, V.; Horley, N.; Williams, I. S.; Joshi, P.; Bharate, S. B.; Jayaprakash, V.; Sinha, B. N.; Chaudhuri, B., Biphenyl urea derivatives as selective CYP1B1 inhibitors. Organic & Biomolecular Chemistry 2016, 14 (38), 8931- 8936. (IF: 3.89)
24. Banerji, Biswadip.; Moumita Chatterjee.; Suvankar Bera.; Mohd Usman Mohd Siddique.; Synthesis of Sulfonamide Derived of New TetrahydroquinazolineDerivatives via Intramolecular Cyclization (2014), JMED Research, Vol. 2014 (2014), Article ID 464776, 10 pages (DOI: 10.5171/2014.464776).
25. Hussain A.; Mohd Usman Mohd Siddique.; Kumar Singh S.; Samad A.; Beg S.; Wais M.; Lipid-Drug Conjugates for Oral Bioavailability Enhancement. Recent Patents on Nanomedicine (2015), 5(2), 87-95.
26. Hussain A.; Samad A.; Mohd Usman Mohd Siddique.; Sharma G.; Lipid-Based Systems for Delivery of Biological Macromolecules. Recent Patents on Nanomedicine 2015, 5(2), 96- 103.
27. Hussain A, Samad A.; Mohd Usman Mohd Siddique.; & Beg S.; Lipid Microparticles for Oral Bioavailability Enhancement. Recent Patents on Nanomedicine (2015), 5(2), 104-110.
28. Patil M, Siddique MU, Sheriker A, Ansari A, Goyal SN, Hasnain MS, Nayak AK. Delivery of genes and growth factors using tailor-made polysaccharides. InTailor-Made Polysaccharides in Drug Delivery 2023 Jan 1 (pp. 377-390). Academic Press.
29. Ansari A, Sheriker A, Siddique MU, Patil M, Goyal SN, Murtuja S, Ahsan MN, Hasnain MS, Nayak AK. Cancer targeting by tailor-made polysaccharides. InTailor-Made Polysaccharides in Drug Delivery 2023 Jan 1 (pp. 347-376). Academic Press.
30. Hasnain MS, Siddique MU, Gadewar MM, Ansari MT, Ahsan MN, Nandi G, Nayak AK. Uses of tailor-made plant starches in drug delivery. InTailor-Made Polysaccharides in Drug Delivery 2023 Jan 1 (pp. 327-346). Academic Press.
31. Hasnain MS, Al-Muhanna MK, Anwar N, Siddique MU, Ahsan MN, Ahmed SA, Ansari MT, Nayak AK. Drug delivery dosage forms made of tailor-made natural polysaccharides. InTailor-Made Polysaccharides in Drug Delivery 2023 Jan 1 (pp. 29-61). Academic Press.
32. Hasnain MS, Al-Muhanna MK, Anwar N, Siddique MU, Ahsan MN, Ahmed SA, Ansari MT, Nayak AK. Drug delivery dosage forms made of tailor-made natural polysaccharides. In Tailor-Made Polysaccharides in Drug Delivery 2023 Jan 1 (pp. 29-61). Academic Press.
